Shrek producer Aaron Warner will make his comics debut for Sea Lion Books.
Pariah will see the Academy Award-winner joined by Eisner-nominated illustrator Brett Weldele and writer Philip Gellat.
The twelve-book graphic novel series follows the adventures of a group of 'vitros' - genetically enhanced children with "beyond-human intelligence" - who go on the run after being framed for the release of a deadly virus.
Warner said: "I came up with Pariah after reading an article about in vitro genetic manipulation. We take medications every day without fully understanding how they work. It's kind of terrifying if you think about it.
"In Pariah, kids grow up with incredible intelligence as a side effect of modern 'cures'. The problem is that they're so smart, they question everything - even things we hold as sacred. All of our laws, morals, and even physical constraints will be torn apart and re-built."
Warner continued: "These kids are adrift in every way, equipped with mental tools we can't even imagine. On top of all of that, they're persecuted, feared and hated. As if being a teenager didn't suck enough."
Sea Lion Books is spearheaded by David Dabel, who is best known for acquiring the comics rights to various properties through his former publishing company Dabel Brothers.
Warner's former Shrek colleague Andrew Adamson was announced as working on an animated movie adaptation of Dark Horse Comics' Beasts of Burden earlier this week.
Pariah will debut in July.
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